Mice are nocturnal and eat throughout the night. To find out what happens when this pattern is disturbed, Dawn Loh and her colleagues at the University of California, Los Angeles, fed one group of mice between 9 pm and 3 am, while another group only had access to food between 9 am and 3 pm. The mice ate this way for two weeks.
Although both groups slept for the same amount of time, the mice that fed during the day had more frequent, shorter bouts of sleep. Their circadian rhythms were out of sync, which affected levels of proteins including one important for learning and memory. The “misaligned” mice also performed less well on memory tests (eLIFE, doi.org/97j).
This article appeared in print under the headline “Midnight feasts hamper memory”